DOAJ Open Access 2025

Development of amyloid‐negative neuropsychological norms using GAMLSS

Sara Rubio‐Guerra María Belén Sánchez‐Saudinós Isabel Sala Laura Videla Alexandre Bejanin +25 lainnya

Abstrak

Abstract INTRODUCTION Recent research has suggested increased sensitivity of Alzheimer's disease (AD)‐negative neuropsychological norms; concurrently, generalized additive models for location, scale, and shape (GAMLSS) have emerged as a promising alternative to traditional norming approaches. Here, we developed amyloid β‐negative (Aβ−) next‐generation norms (NGN) for a comprehensive neuropsychological battery using GAMLSS. METHODS We included N = 987 cognitively normal (CN) individuals from a Spanish multicenter study with extensive neuropsychological data and cerebrospinal fluid AD biomarker assessment. NGN were developed using GAMLSS based on the performance of n = 774 Aβ− CN individuals aged 30–90 years. RESULTS Age‐, education‐, and sex‐adjusted z‐scores were obtained for 14 measures covering the main cognitive domains (memory, language, attention/executive, and visuospatial functions). A user‐friendly calculator for the z‐scores was made available in an open‐access ShinyApp to facilitate their application. DISCUSSION NGN may improve the detection of objective cognitive impairment in clinical and research settings. Highlights Brain amyloid β (Aβ) is associated with poorer performance in cognitively normal individuals. We provide GAMLSS‐based Aβ‐negative norms for 14 neuropsychological measures. Age, education, and often sex significantly influence cognitive performance. An online calculator for the demographically adjusted z‐scores is freely available.

Topik & Kata Kunci

Neurology. Diseases of the nervous system Geriatrics

Penulis (30)

Sara Rubio‐Guerra

María Belén Sánchez‐Saudinós

Isabel Sala

Laura Videla

Alexandre Bejanin

Ainara Estanga

Mirian Ecay‐Torres

Carolina Lopez deLuis

Lorena Rami

Adrià Tort‐Merino

Magdalena Castellví

Ana Pozueta

María García‐Martínez

David Gómez‐Andrés

Carmen Lage

Sara López‐García

Pascual Sánchez‐Juan

Mircea Balasa

Albert Lladó

Miren Altuna

Mikel Tainta

Javier Arranz

Nuole Zhu

Daniel Alcolea

Alberto Lleó

Juan Fortea

Eloy Rodríguez Rodríguez

Raquel Sánchez‐Valle

Pablo Martínez‐Lage

Ignacio Illán‐Gala

Format Sitasi

APA MLA BibTeX

Rubio‐Guerra, S., Sánchez‐Saudinós, M.B., Sala, I., Videla, L., Bejanin, A., Estanga, A. et al. (2025). Development of amyloid‐negative neuropsychological norms using GAMLSS. https://doi.org/10.1002/dad2.70224

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.1002/dad2.70224

Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1002/dad2.70224
Akses: Open Access ✓