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CrossRef Open Access 2024 3 sitasi

Synthesis of New Isoxazolidine Derivatives Utilizing the Functionality of N-Carbonylpyrazol-Linked Isoxazolidines

Xixian Cao Jun You Yunze Wang Yanchao Yu Wenju Wu +1 lainnya
Lihat Sumber DOI

Abstrak

Using Ni(II) as the catalyst, electron-deficient 3,5-dimethylacryloylpyrazole olefin was reacted with C,N-diarylnitrones alone for 10 min to prepare novel five-member heterocyclic products, 4-3,5-dimethylacryloylpyrazole isoxazolidines with 100% regioselectivity and up to 99% yield. And then, taking these cycloadducts as substrates, six kinds of derivatization reactions, like ring-opening, nucleophilic substitution, addition-elimination and reduction, were studied. Experimental results showed that all kinds of transformations could obtain the target products at a high conversion rate under mild conditions, a finding which provided the basic methods for organic synthesis methodology research based on an isoxazolidine skeleton.

Penulis (6)

X

Xixian Cao

J

Jun You

Y

Yunze Wang

Y

Yanchao Yu

W

Wenju Wu

Y

Yifang Liang

Format Sitasi

APA MLA BibTeX
Cao, X., You, J., Wang, Y., Yu, Y., Wu, W., Liang, Y. (2024). Synthesis of New Isoxazolidine Derivatives Utilizing the Functionality of N-Carbonylpyrazol-Linked Isoxazolidines. https://doi.org/10.3390/molecules29153454

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Informasi Jurnal
Tahun Terbit
2024
Bahasa
en
Total Sitasi
3×
Sumber Database
CrossRef
DOI
10.3390/molecules29153454
Akses
Open Access ✓