Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review
Abstrak
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.
Penulis (22)
Kaja Troha
Domen Vozel
Matevž Arko
Apolonija Bedina Zavec
Drago Dolinar
Matej Hočevar
Zala Jan
Matic Kisovec
Boštjan Kocjančič
Ljubiša Pađen
Manca Pajnič
Samo Penič
Anna Romolo
Neža Repar
Vesna Spasovski
Nejc Steiner
Vid Šuštar
Aleš Iglič
Damjana Drobne
Ksenija Kogej
Saba Battelino
Veronika Kralj-Iglič
Akses Cepat
- Tahun Terbit
- 2023
- Bahasa
- en
- Total Sitasi
- 23×
- Sumber Database
- CrossRef
- DOI
- 10.3390/ijms24043420
- Akses
- Open Access ✓