CrossRef Open Access 2025 41 sitasi

The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases

Eliane Münte Phillipp Hartmann

Abstrak

With its increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a major global public health concern over the past few decades. Growing evidence has proposed the microbiota-derived metabolites short-chain fatty acids (SCFAs) as a potential factor in the pathophysiology of MASLD and related metabolic conditions, such as obesity and type 2 diabetes mellitus (T2DM). By influencing key pathways involved in energy homeostasis, insulin sensitivity, and inflammation, SCFAs play an important role in gut microbiota composition, intestinal barrier function, immune modulation, and direct metabolic signaling. Furthermore, recent animal and human studies on therapeutic strategies targeting SCFAs demonstrate their potential for treating these metabolic disorders.

Penulis (2)

Eliane Münte

Phillipp Hartmann

Format Sitasi

APA MLA BibTeX

Münte, E., Hartmann, P. (2025). The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases. https://doi.org/10.3390/biom15040469

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.3390/biom15040469

Informasi Jurnal

Tahun Terbit: 2025
Bahasa: en
Total Sitasi: 41×
Sumber Database: CrossRef
DOI: 10.3390/biom15040469
Akses: Open Access ✓