THE EVALUATION OF IMPACT OF FEMALE BODY MASS INDEX ON RESULTS OF TREATMENT OF INFERTILITY USING METHOD OF AUXILIARY REPRODUCTIVE TECHNOLOGIES

The overweight and obesity acquire character of global epidemic, negatively affecting female fertility. The association between increased body mass index and infertility conditions higher need in application of auxiliary reproductive technologies (ART) in this category of female patients. The results of studies of affect of body mass index on efficiency of ART demonstrate certain heterogeneity. The purpose of the study is to investigate affect of overweight on results of treatment of infertility using method of auxiliary reproductive technologies. The retrospective analysis covered 1840 women treated by ART. The criteria of selection were age 30–35 years, isolated female uterine factor of infertility, single embryo transfer. The exclusion criteria were decreased ovarian reserve, multifetation, programs with donor cells. The body mass index was stratified into four categories according WHO classification. The prevalence of overweight and obesity made up to 20.2% and 16.8% correspondingly. The significant differences were found in group with obesity (BMI≥30 kg/m²): live birth rate was 1.6 times lower and miscarriage rate was 1.8 times higher as compared to group with normal weight. In case of obesity degree II (BMI 35.0–39.9 kg/m²): pregnancy rate was 1.3 times lower, live birth rate was 2.07 times lower and miscarriage rate was 2.26 times higher. The significant affection of BMI on efficiency of ART programs was established. Considering increased maternal and perinatal risks, female patients with overweight and obesity are recommended to decrease their weight before starting ART treatment.