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CrossRef Open Access 2022 26 sitasi

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle

María Eugenia Cortina R. Clayton Bishop Brittany A. DeVasure Isabelle Coppens Isabelle Derré
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Abstrak

All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion. Chlamydia specific Type III secreted effectors, known as inclusion membrane proteins (Inc), are embedded into the inclusion membrane. Progression through the developmental cycle, in particular early events of conversion from infectious (EB) to replicative (RB) bacteria, is important for intracellular replication, but poorly understood. Here, we identified the inclusion membrane protein IncS as a critical factor for Chlamydia development. We show that a C . trachomatis conditional mutant is impaired in transition from EB to RB in human cells, and C . muridarum mutant bacteria fail to develop in a mouse model of Chlamydia infection. Thus, IncS represents a promising target for therapeutic intervention of the leading cause of sexually transmitted infections of bacterial origin.

Penulis (5)

M

María Eugenia Cortina

R

R. Clayton Bishop

B

Brittany A. DeVasure

I

Isabelle Coppens

I

Isabelle Derré

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APA MLA BibTeX
Cortina, M.E., Bishop, R.C., DeVasure, B.A., Coppens, I., Derré, I. (2022). The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle. https://doi.org/10.1371/journal.ppat.1010818

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Lihat di Sumber doi.org/10.1371/journal.ppat.1010818
Informasi Jurnal
Tahun Terbit
2022
Bahasa
en
Total Sitasi
26×
Sumber Database
CrossRef
DOI
10.1371/journal.ppat.1010818
Akses
Open Access ✓