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CrossRef Open Access 2011 8 sitasi

Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency of<i>Myd88</i>and<i>IFNAR</i>Genes

Javier Vaquero Kimberly J. Riehle Nelson Fausto Jean S. Campbell
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Abstrak

Liver regeneration is known to occur in mice lacking one or more Toll-like receptors (TLRs) or the adaptor protein MyD88. Though MyD88 is required for signaling by many TLRs, others signal via MyD88-independent pathways, leading to the induction of type I interferons (IFNs). Here, we assessed liver regeneration after partial hepatectomy (PH) in mice lacking both MyD88 and the type I IFN receptor (Myd88-IFNARdouble-KO). Approximately 28% ofMyd88-IFNARdouble-KO mice had gross liver lesions prior to surgery. In mice without lesions,Myd88-IFNARdeficiency abrogated the increase in circulating IL-6 after PH but did not impair hepatocyte BrdU incorporation, mitotic figure counts, or recovery of liver-to-body weight ratios. These results indicate that type I IFNs are not responsible for the preservation of liver regeneration inMyd88-deficient mice, and they also cast doubt on the idea of microbial products being essential triggers of liver regeneration in mice undergoing PH.

Penulis (4)

J

Javier Vaquero

K

Kimberly J. Riehle

N

Nelson Fausto

J

Jean S. Campbell

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APA MLA BibTeX
Vaquero, J., Riehle, K.J., Fausto, N., Campbell, J.S. (2011). Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency of<i>Myd88</i>and<i>IFNAR</i>Genes. https://doi.org/10.1155/2011/727403

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Lihat di Sumber doi.org/10.1155/2011/727403
Informasi Jurnal
Tahun Terbit
2011
Bahasa
en
Total Sitasi
8×
Sumber Database
CrossRef
DOI
10.1155/2011/727403
Akses
Open Access ✓