Vaccine effectiveness against COVID‐19 among symptomatic persons aged ≥12 years with reported contact with COVID‐19 cases, February–September 2021
Abstrak
Abstract Background Individuals in contact with persons with COVID‐19 are at high risk of developing COVID‐19; protection offered by COVID‐19 vaccines in the context of known exposure is poorly understood. Methods Symptomatic outpatients aged ≥12 years reporting acute onset of COVID‐19‐like illness and tested for SARS‐CoV‐2 between February 1 and September 30, 2021 were enrolled. Participants were stratified by self‐report of having known contact with a COVID‐19 case in the 14 days prior to illness onset. Vaccine effectiveness was evaluated using the test‐negative study design and multivariable logistic regression. Results Among 2229 participants, 283/451 (63%) of those reporting contact and 331/1778 (19%) without known contact tested SARS‐CoV‐2‐positive. Adjusted vaccine effectiveness was 71% (95% confidence interval [CI], 49%–83%) among fully vaccinated participants reporting a known contact versus 80% (95% CI, 72%–86%) among those with no known contact ( p ‐value for interaction = 0.2). Conclusions This study contributes to growing evidence of the benefits of vaccinations in preventing COVID‐19 and support vaccination recommendations and the importance of efforts to increase vaccination coverage.
Penulis (18)
Jessie R. Chung
Sara S. Kim
Edward A. Belongia
Huong Q. McLean
Jennifer P. King
Mary Patricia Nowalk
Richard K. Zimmerman
Krissy Moehling Geffel
Emily T. Martin
Arnold S. Monto
Lois E. Lamerato
Manjusha Gaglani
Eric Hoffman
Marcus Volz
Michael L. Jackson
Lisa A. Jackson
Manish M. Patel
Brendan Flannery
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2022
- Bahasa
- en
- Total Sitasi
- 5×
- Sumber Database
- CrossRef
- DOI
- 10.1111/irv.12973
- Akses
- Open Access ✓