Environmental Endocrine‐Disrupting Chemicals, Pancreatic β‐Cells, and Type 2 Diabetes Mellitus
Abstrak
ABSTRACT Objective To clarify the link between environmental pollution and diabetes risk by focusing on pancreatic β‐cells as key targets of environmental insults, with emphasis on the role of endocrine‐disrupting chemicals (EDCs) in pancreatic dysfunction and diabetes pathogenesis. Methods This narrative review synthesises recent research on EDCs, focusing on their effects on β‐cells. The literature search included studies in English on EDCs, diabetes, and β‐cell function, utilising Boolean operators to refine the search. Results EDCs impair β‐cell function through mechanisms such as oxidative stress, mitochondrial damage, and epigenetic changes. These pollutants disrupt insulin synthesis, secretion, and β‐cell survival, which is distinct from their general metabolic effects. Additionally, EDCs may interact synergistically with traditional diabetes risk factors, such as high‐fat diets, amplifying the risk of diabetes. Conclusion Environmental pollutants play a significant role in β‐cell dysfunction and diabetes, offering new directions for research and prevention.
Penulis (2)
Yan‐li Zhao
Yang Ou
Akses Cepat
- Tahun Terbit
- 2025
- Bahasa
- en
- Total Sitasi
- 1×
- Sumber Database
- CrossRef
- DOI
- 10.1111/cen.70050
- Akses
- Open Access ✓