Insulin‐like growth factor‐<scp>II</scp>: its role in metabolic and endocrine disease
Abstrak
SummaryInsulin‐like growth factor‐II (IGF‐II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF‐I. IGF‐II regulates foetal development and differentiation, but its role in adults is less well understood. Evidence suggests roles in a number of tissues including skeletal muscle, adipose tissue, bone and ovary. Altered IGF‐II expression has been observed in metabolic conditions, notably obesity, diabetes and the polycystic ovary syndrome. This article summarizes what is known about the actions of IGF‐II and its dysregulation in metabolic and endocrine diseases. The possible causes and consequences of dysregulation are discussed along with the implications for diagnostic tests and future research.
Penulis (2)
Callum Livingstone
Anwar Borai
Akses Cepat
- Tahun Terbit
- 2014
- Bahasa
- en
- Total Sitasi
- 119×
- Sumber Database
- CrossRef
- DOI
- 10.1111/cen.12446
- Akses
- Open Access ✓