CoRa –A general approach for quantifying biological feedback control
Abstrak
Abstract Feedback control is a fundamental underpinning of life, underlying homeostasis of biological processes at every scale of organization, from cells to ecosystems. The ability to evaluate the contribution and limitations of feedback control mechanisms operating in cells is a critical step for understanding and ultimately designing feedback control systems with biological molecules. Here, we introduce CoRa –or Co ntrol Ra tio –, a general framework that quantifies the contribution of a biological feedback control mechanism to adaptation using a mathematically controlled comparison to an identical system that does not contain the feedback. CoRa provides a simple and intuitive metric with broad applicability to biological feedback systems.
Penulis (2)
Mariana Gómez-Schiavon
Hana El-Samad
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Sumber Database
- CrossRef
- DOI
- 10.1101/2020.10.09.334078
- Akses
- Open Access ✓