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CrossRef Open Access 2024 4 sitasi

Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH

Afzaal Tufail Saeed Akkad Natasha E. Hatton Nicholas D. J. Yates Richard J. Spears +4 lainnya
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Abstrak

Bioconjugation at N-terminal α-oxo aldehydes is challenging when proline is adjacent due to competing cyclisation. In this study we show aldol bioconjugations can outcompete this cyclisation at acidic pH in modifications of peptides and proteins.

Penulis (9)

A

Afzaal Tufail

S

Saeed Akkad

N

Natasha E. Hatton

N

Nicholas D. J. Yates

R

Richard J. Spears

T

Tessa Keenan

A

Alison Parkin

N

Nathalie Signoret

M

Martin A. Fascione

Format Sitasi

APA MLA BibTeX
Tufail, A., Akkad, S., Hatton, N.E., Yates, N.D.J., Spears, R.J., Keenan, T. et al. (2024). Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH. https://doi.org/10.1039/d3ra08776j

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Informasi Jurnal
Tahun Terbit
2024
Bahasa
en
Total Sitasi
4×
Sumber Database
CrossRef
DOI
10.1039/d3ra08776j
Akses
Open Access ✓