CrossRef Open Access 2024 4 sitasi

Integration-free induced pluripotent stem cells from three endangered Southeast Asian non-human primate species

Qiuye Bao Nicole Liling Tay Christina Yingyan Lim Delia Hwee Hoon Chua Su Keyau Kee +4 lainnya

Lihat Sumber DOI

Abstrak

AbstractAdvanced molecular and cellular technologies provide promising tools for wildlife and biodiversity conservation. Induced pluripotent stem cell (iPSC) technology offers an easily accessible and infinite source of pluripotent stem cells, and have been derived from many threatened wildlife species. This paper describes the first successful integration-free reprogramming of adult somatic cells to iPSCs, and their differentiation, from three endangered Southeast Asian primates: the Celebes Crested Macaque (Macaca nigra), the Lar Gibbon (Hylobates lar), and the Siamang (Symphalangus syndactylus). iPSCs were also generated from the Proboscis Monkey (Nasalis larvatus). Differences in mechanisms could elicit new discoveries regarding primate evolution and development. iPSCs from endangered species provides a safety net in conservation efforts and allows for sustainable sampling for research and conservation, all while providing a platform for the development of further in vitro models of disease.

Penulis (9)

Qiuye Bao

Nicole Liling Tay

Christina Yingyan Lim

Delia Hwee Hoon Chua

Su Keyau Kee

Mahesh Choolani

Yuin-Han Loh

Soon Chye Ng

Chou Chai

Format Sitasi

APA MLA BibTeX

Bao, Q., Tay, N.L., Lim, C.Y., Chua, D.H.H., Kee, S.K., Choolani, M. et al. (2024). Integration-free induced pluripotent stem cells from three endangered Southeast Asian non-human primate species. https://doi.org/10.1038/s41598-023-50510-9

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41598-023-50510-9

Informasi Jurnal

Tahun Terbit: 2024
Bahasa: en
Total Sitasi: 4×
Sumber Database: CrossRef
DOI: 10.1038/s41598-023-50510-9
Akses: Open Access ✓