Relationships between Octanol‐Water Partition Data, Chromatographic Indices and Their Dependence on pH in a Set of Nonsteroidal Anti‐Inflammatory Drugs
Abstrak
AbstractOctanol/water partition and distribution coefficients of a set of nonsteroidal anti‐inflammatory drugs were measured. Relationships between partition data at different pH values and dissociation constants are discussed.Log k′ values were determined by reversed‐phase high‐performance liquid chromatography (HPLC) on bonded octyl and octadecylsilane supports at different pH values using various organic modifiers in the mobile phase.The log k′ values exhibited linear relationships with methanol concentration in the mobile phase. Octanol/water partition data correlated well with the extrapolated log k′ indices to zero methanol concentration (solvent regression equations) and with the corresponding Rm indices measured on octyl and octadecyl reversed phases thin layer chromatography (HPTLC). Nature of the slopes and the intercepts of the relationships is discussed.It is shown that the HPLC and HPTLC methods are useful alternatives for the determination of partition data.
Penulis (5)
Maria Immacolata La Rotonda
Gaetano Amato
Francesco Barbato
Carlo Silipo
Antonio Vittoria
Akses Cepat
- Tahun Terbit
- 1983
- Bahasa
- en
- Total Sitasi
- 26×
- Sumber Database
- CrossRef
- DOI
- 10.1002/qsar.19830020405
- Akses
- Open Access ✓