CrossRef Open Access 2020 6 sitasi

Tetrabutylammonium HPLC analysis: shortcomings in the Ph. Eur. method

Anna Bogni Luca Laera Claudio Cucchi Ettore Seregni Claudio Pascali

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Abstrak

AbstractTetrabutylammonium is a phase‐transfer agent commonly used in PET radiochemistry. Its toxicity makes its quantification mandatory. However, the official HPLC method for tetrabutylammonium analysis reported in the European Pharmacopoeia (Ph. Eur.) apparently fails to achieve the described separation in most new generation reverse‐phase columns. The study highlights the differences in separation achievable by varying some of the chromatographic conditions, such as temperature, eluent composition and ion‐pairing agent concentration. In the end, variations to the method within the limits allowed by the Ph. Eur. were not sufficient to overcome the problem, thus forcing to a more radical change of the organic component of the mobile phase.

Penulis (5)

Anna Bogni

Luca Laera

Claudio Cucchi

Ettore Seregni

Claudio Pascali

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APA MLA BibTeX

Bogni, A., Laera, L., Cucchi, C., Seregni, E., Pascali, C. (2020). Tetrabutylammonium HPLC analysis: shortcomings in the Ph. Eur. method. https://doi.org/10.1002/jlcr.3822

Akses Cepat

Lihat di Sumber doi.org/10.1002/jlcr.3822

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 6×
Sumber Database: CrossRef
DOI: 10.1002/jlcr.3822
Akses: Open Access ✓