CrossRef Open Access 2022 7 sitasi

Construction of <scp>pH</scp>‐responsive core crosslinked micelles via thiol‐yne click reaction

Yile Niu Yanbing Lu

Lihat Sumber DOI

Abstrak

AbstractPolycarbonate‐based micelles possessed enormous potential for hydrophobic drug delivery. To improve micelle stability and prevent premature leakage during blood circulation, photo‐induced thiol‐yne click reaction was utilized to construct polycarbonate‐based core crosslinked micelles (CCLMs), which avoided the use of toxic copper catalyst. The introduced β‐thiopropionate linkage in the core was demonstrated to endow the CCLMs with pH‐responsiveness. The obtained CCLMs showed good dilution stability against DMF and water. Further MTT assays demonstrated excellent biocompatibility and low toxicity of the CCLMs in HeLa/MCF‐7 cells. Moreover, DOX‐encapsulated CCLMs showed good anticancer effects and excellent internalization efficiency in HeLa cells. The pH‐responsive polycarbonate‐based CCLMs by thiol‐yne click reaction have potential used as smart delivery systems for controlled drug release.

Penulis (2)

Yile Niu

Yanbing Lu

Format Sitasi

APA MLA BibTeX

Niu, Y., Lu, Y. (2022). Construction of <scp>pH</scp>‐responsive core crosslinked micelles via thiol‐yne click reaction. https://doi.org/10.1002/app.52753

Akses Cepat

Lihat di Sumber doi.org/10.1002/app.52753

Informasi Jurnal

Tahun Terbit: 2022
Bahasa: en
Total Sitasi: 7×
Sumber Database: CrossRef
DOI: 10.1002/app.52753
Akses: Open Access ✓