Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
Abstrak
Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening of the Escherichia coli and Saccharomyces cerevisiae transcriptional regulatory networks at a small number (3-5) selected nodes can have a greater impact than the complete elimination of a single selected node. In both cases, the targeted nodes have the greatest possible impact; still the results suggest that in some cases broad specificity compounds or multitarget drug therapies may be more effective than individual high-affinity, high-specificity ones. Multiple but partial attacks mimic well a number of in vivo scenarios and may be useful in the efficient modification of other complex systems.
Penulis (3)
Vilmos Agoston
Peter Csermely
Sandor Pongor
Akses Cepat
- Tahun Terbit
- 2004
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓