arXiv
Open Access
2025
Biomolecular LQR under Partial Observation
Xiaoyu Zhang
Zhou Fang
Abstrak
This paper introduces a biomolecular Linear Quadratic Regulator (LQR) to investigate the design principles of gene regulatory networks. We show that for fundamental gene regulation network, the bio-controller derived from LQR theory precisely recapitulate natural network motifs, such as auto-regulation and incoherent feedforward loops. This emulation arises from a fundamental principle: the LQR cost function mathematically encodes environmental survival demands, which subsequently drives the selection of both network topology and biochemical parameters. Our work thus establishes a theoretical basis for interpreting biological circuit design, directly linking evolutionary pressures to observable regulatory structures.
Penulis (2)
X
Xiaoyu Zhang
Z
Zhou Fang
Akses Cepat
Informasi Jurnal
- Tahun Terbit
- 2025
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- en
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- arXiv
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- Open Access ✓