arXiv Open Access 2025

From Fiber Tracts to Tumor Spread: Biophysical Modeling of Butterfly Glioma Growth Using Diffusion Tensor Imaging

Jonas Weidner Ivan Ezhov Michal Balcerak André Datchev Lucas Zimmer +3 lainnya

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Abstrak

Butterfly tumors are a distinct class of gliomas that span the corpus callosum, producing a characteristic butterfly-shaped appearance on MRI. The distinctive growth pattern of these tumors highlights how white matter fibers and structural connectivity influence brain tumor cell migration. To investigate this relation, we applied biophysical tumor growth models to a large patient cohort, systematically comparing models that incorporate fiber tract information with those that do not. Our results demonstrate that including fiber orientation data significantly improves model accuracy, particularly for a subset of butterfly tumors. These findings highlight the critical role of white matter architecture in tumor spread and suggest that integrating fiber tract information can enhance the precision of radiotherapy target volume delineation.

Topik & Kata Kunci

physics.med-ph

Penulis (8)

Jonas Weidner

Ivan Ezhov

Michal Balcerak

André Datchev

Lucas Zimmer

Daniel Rueckert

Björn Menze

Benedikt Wiestler

Format Sitasi

APA MLA BibTeX

Weidner, J., Ezhov, I., Balcerak, M., Datchev, A., Zimmer, L., Rueckert, D. et al. (2025). From Fiber Tracts to Tumor Spread: Biophysical Modeling of Butterfly Glioma Growth Using Diffusion Tensor Imaging. https://arxiv.org/abs/2507.17707

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Informasi Jurnal

Tahun Terbit: 2025
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓