Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time
Abstrak
Plastics are essential to modern life, yet poor disposal practices contribute to low recycling rates and environmental accumulation-biological degradation and by-product reuse offer a path to mitigate this global threat. This report highlights key insights, future challenges, and research priorities identified during the CECAM workshop "Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time", held in Trieste from May 6-8, 2025. The workshop brought together an interdisciplinary community of scientists focused on advancing the sustainable use of plastics through enzyme-based degradation. A key point from the discussions is that many bottlenecks in enzymatic recycling arise not only from process engineering challenges, but also from a limited understanding of the underlying molecular mechanisms. We argue that constraints on economic viability and sustainability (e.g., harsh solvents, high temperatures, substrate crystallinity, pretreatments) can-and should-be addressed directly through enzyme design, provided these factors are understood at the molecular level, in synergy with process optimization. For this, it is essential to rely on the integration of experimental and computational approaches to uncover the molecular and mechanistic basis of enzymatic plastic degradation. We highlight how the small-format structure of the workshop, in line with the usual CECAM format, fostered a collaborative, friendly, and relaxed atmosphere. We hope this report encourages future initiatives and the formation of shared consortia to support an open, collaborative, and bio-based plastic recycling community.
Topik & Kata Kunci
Penulis (42)
Francesco Colizzi
Paula Blázquez-Sánchez
Giovanni Bussi
Isabelle André
Federico Ballabio
Thomas Bayer
Federica Bertocchini
Erik Butenschön
Emanuele Carosati
Alessia De Piero
Ania Di Pede-Mattatelli
Leonardo Faggian
Lorenzo Favaro
Pedro Alexandrino Fernandes
Alfonso Ferretti
Peter Fojan
Andreas Gagsteiger
Eva García-Ruiz
Lucia Gardossi
Toni Giorgino
Norbert Graefe
Jonas Gunkel
Diego J. Jiménez
Malene Billeskov Keller
Georg Künze
Sierin Lim
Guy Lippens
Miguel A. Maria-Solano
Karolina Mitusińska
Vicent Moliner
Gianluca Molla
Marthinus Wessel Myburgh
Nicolas Panel
César A. Ramírez-Sarmiento
Dominique Rocher
Birgit Strodel
Belén Taroncher Ruiz
Onur Turak
Cristiano Varrone
Daniele Vezzini
Peter Westh
Wolfgang Zimmermann
Akses Cepat
- Tahun Terbit
- 2025
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓