arXiv
Open Access
2023
Stress-Induced Mutagenesis Can Further Boost Population Success in Static Ecology
Kien T. Pham
Duc M. Nguyen
Duy V. Tran
Vi D. Ao
Huy D. Tran
+2 lainnya
Abstrak
We have developed a mathematical model that captures stress-induced mutagenesis, a fundamental aspect of pathogenic and neoplastic evolutionary dynamics, on the fitness landscape with multiple relevant genetic traits as a high-dimensional Euclidean space. In this framework, stress-induced mutagenesis manifests as a heterogeneous diffusion process. We show how increasing mutations, and thus reducing exploitation, in a static ecology with fixed carrying capacity and maximum growth rates, can paradoxically boost population size. Remarkably, this unexpected biophysical phenomenon applies universally to any number of traits.
Topik & Kata Kunci
Penulis (7)
K
Kien T. Pham
D
Duc M. Nguyen
D
Duy V. Tran
V
Vi D. Ao
H
Huy D. Tran
T
Tuan K. Do
T
Trung V. Phan
Akses Cepat
Informasi Jurnal
- Tahun Terbit
- 2023
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓