arXiv Open Access 2021

Artifacts in optical projection tomography due to refractive index mismatch: model and correction

Yan Liu Jonathan Dong Cédric Schmidt Aleix Boquet-Pujadas Jérôme Extermann +1 lainnya

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Abstrak

Optical Projection Tomography (OPT) is a powerful tool for 3D imaging of mesoscopic samples, thus of great importance to image whole organs for the study of various disease models in life sciences. OPT is able to achieve resolution at a few tens of microns over a large sample volume of several cubic centimeters. However, the reconstructed OPT images often suffer from artifacts caused by different kinds of physical miscalibration. This work focuses on the refractive index (RI) mismatch between the rotating object and the surrounding medium. We derive a 3D cone beam forward model to approximate the effect of RI mismatch and implement a fast and efficient reconstruction method to correct the induced seagull-shaped artifacts on experimental images of fluorescent beads.

Topik & Kata Kunci

physics.optics eess.IV physics.med-ph

Penulis (6)

Yan Liu

Jonathan Dong

Cédric Schmidt

Aleix Boquet-Pujadas

Jérôme Extermann

Michael Unser

Format Sitasi

APA MLA BibTeX

Liu, Y., Dong, J., Schmidt, C., Boquet-Pujadas, A., Extermann, J., Unser, M. (2021). Artifacts in optical projection tomography due to refractive index mismatch: model and correction. https://arxiv.org/abs/2112.12602

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Informasi Jurnal

Tahun Terbit: 2021
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓