arXiv Open Access 2020

Hindering loads prompt clustered configurations that enhance stability during cargo transport by multiple Kinesin-1

Shreyas Bhaban Rachit Srivastava James Melbourne Saurav Talukdar Murti V. Salapaka

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Abstrak

Transport of intracellular cargo is often mediated by teams of molecular motors that function in a chaotic environment under varying conditions. We show that the motors have unique steady state behavior which enables transport modalities that are robust. Under reduced ATP concentrations, multi-motor configurations are preferred over single motors. Higher load force drives motors to cluster, but very high loads compel them to separate in a manner that promotes immediate cargo movement once the load subsides. These inferences, backed by analytical guarantees, provide unique insights into the coordination strategies adopted by molecular motors to transport intracellular cargo.

Topik & Kata Kunci

q-bio.SC

Penulis (5)

Shreyas Bhaban

Rachit Srivastava

James Melbourne

Saurav Talukdar

Murti V. Salapaka

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APA MLA BibTeX

Bhaban, S., Srivastava, R., Melbourne, J., Talukdar, S., Salapaka, M.V. (2020). Hindering loads prompt clustered configurations that enhance stability during cargo transport by multiple Kinesin-1. https://arxiv.org/abs/2007.02206

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Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓