arXiv Open Access 2020

Opportunities at the interface of network science and metabolic modelling

Varshit Dusad Denise Thiel Mauricio Barahona Hector C. Keun Diego A. Oyarzún

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Abstrak

Metabolism plays a central role in cell physiology because it provides the molecular machinery for growth. At the genome-scale, metabolism is made up of thousands of reactions interacting with one another. Untangling this complexity is key to understand how cells respond to genetic, environmental, or therapeutic perturbations. Here we discuss the roles of two complementary strategies for the analysis of genome-scale metabolic models: Flux Balance Analysis (FBA) and network science. While FBA estimates metabolic flux on the basis of an optimisation principle, network approaches reveal emergent properties of the global metabolic connectivity. We highlight how the integration of both approaches promises to deliver insights on the structure and function of metabolic systems with wide-ranging implications in discovery science, precision medicine and industrial biotechnology.

Topik & Kata Kunci

q-bio.MN q-bio.QM

Penulis (5)

Varshit Dusad

Denise Thiel

Mauricio Barahona

Hector C. Keun

Diego A. Oyarzún

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APA MLA BibTeX

Dusad, V., Thiel, D., Barahona, M., Keun, H.C., Oyarzún, D.A. (2020). Opportunities at the interface of network science and metabolic modelling. https://arxiv.org/abs/2006.03286

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Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓