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arXiv Open Access 2020

Inverse Problems of Single Molecule Localization Microscopy

Montse Lopez-Martinez Gwenael Mercier Kamran Sadiq Otmar Scherzer Magdalena Schneider +3 lainnya
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Abstrak

Single molecule localization microscopy is a recently developed superresolution imaging technique to visualize structural properties of single cells. The basic principle consists in chemically attaching fluorescent dyes to the molecules, which after excitation with a strong laser may emit light. To achieve superresolution, signals of individual fluorophores are separated in time. In this paper we follow the physical and chemical literature and derive mathematical models describing the propagation of light emitted from dyes in single molecule localization microscopy experiments via Maxwell's equations. This forms the basis of formulating inverse problems related to single molecule localization microscopy. We also show that the current status of reconstruction methods is a simplification of more general inverse problems for Maxwell's equations as discussed here.

Topik & Kata Kunci

physics.optics

Penulis (8)

M

Montse Lopez-Martinez

G

Gwenael Mercier

K

Kamran Sadiq

O

Otmar Scherzer

M

Magdalena Schneider

J

John C Schotland

G

Gerhard J. Schütz

R

Roger Telschow

Format Sitasi

APA MLA BibTeX
Lopez-Martinez, M., Mercier, G., Sadiq, K., Scherzer, O., Schneider, M., Schotland, J.C. et al. (2020). Inverse Problems of Single Molecule Localization Microscopy. https://arxiv.org/abs/2002.01741

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Informasi Jurnal
Tahun Terbit
2020
Bahasa
en
Sumber Database
arXiv
Akses
Open Access ✓