Stochastic single-molecule dynamics of synaptic membrane protein domains
Abstrak
Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes. We find that the stochastic reaction-diffusion dynamics of synaptic proteins provide a simple physical mechanism for collective fluctuations in synaptic domains, the molecular turnover observed at synaptic domains, key features of the single-molecule trajectories observed for synaptic proteins, and spatially inhomogeneous protein lifetimes at the cell membrane. Our results suggest that central aspects of the single-molecule and collective dynamics observed for membrane protein domains can be understood in terms of stochastic reaction-diffusion processes at the cell membrane.
Topik & Kata Kunci
Penulis (3)
Osman Kahraman
Yiwei Li
Christoph A. Haselwandter
Akses Cepat
- Tahun Terbit
- 2016
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓