arXiv Open Access 2016

Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading

Pierre Gaspard

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Abstrak

Kinetic theory and thermodynamics are applied to DNA polymerases with exonuclease activity, taking into account the dependence of the rates on the previously incorportated nucleotide. The replication fidelity is shown to increase significantly thanks to this dependence at the basis of the mechanism of exonuclease proofreading. In particular, this dependence can provide up to a hundred-fold lowering of the error probability under physiological conditions. Theory is compared with numerical simulations for the DNA polymerases of T7 viruses and human mitochondria.

Topik & Kata Kunci

q-bio.SC physics.bio-ph

Penulis (1)

Pierre Gaspard

Format Sitasi

APA MLA BibTeX

Gaspard, P. (2016). Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading. https://arxiv.org/abs/1604.02554

Akses Cepat

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Informasi Jurnal

Tahun Terbit: 2016
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓