arXiv Open Access 2012

Optimal Placement of Origins for DNA Replication

Jens Karschau J. Julian Blow Alessandro P. S. de Moura

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Abstrak

DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyse these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.

Topik & Kata Kunci

q-bio.QM cond-mat.stat-mech physics.bio-ph q-bio.SC

Penulis (3)

Jens Karschau

J. Julian Blow

Alessandro P. S. de Moura

Format Sitasi

APA MLA BibTeX

Karschau, J., Blow, J.J., Moura, A.P.S.d. (2012). Optimal Placement of Origins for DNA Replication. https://arxiv.org/abs/1202.0433

Akses Cepat

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Informasi Jurnal

Tahun Terbit: 2012
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓