Cooperative protein transport in cellular organelles
Abstrak
Compartmentalization into biochemically distinct organelles constantly exchanging material is one of the hallmarks of eukaryotic cells. In the most naive picture of inter-organelle transport driven by concentration gradients, concentration differences between organelles should relax. We determine the conditions under which cooperative transport, i.e. based on molecular recognition, allows for the existence and maintenance of distinct organelle identities. Cooperative transport is also shown to control the flux of material transiting through a compartmentalized system, dramatically increasing the transit time under high incoming flux. By including chemical processing of the transported species, we show that this property provides a strong functional advantage to a system responsible for protein maturation and sorting.
Topik & Kata Kunci
Penulis (2)
Serge Dmitrieff
Pierre Sens
Akses Cepat
- Tahun Terbit
- 2011
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓